2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106454R
    N-Desalkylflurazepam (Standard)
    		Inhibitor
    N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively.
    N-Desalkylflurazepam (Standard)
  • HY-101685A
    Iganidipine di(hydrochloride)
    		Antagonist
    Iganidipine dihydrochloride is a Ca2+ antagonist.
    Iganidipine di(hydrochloride)
  • HY-14284S
    Nilvadipine-d4
    		Antagonist
    Nilvadipine-d4 is deuterium labeled Nilvadipine. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
    Nilvadipine-d<sub>4</sub>
  • HY-50722A
    (Rac)-NNC 55-0396
    		Control
    (Rac)-NNC 55-0396 is the racemate of NNC 55-0396 (HY-50722).
    (Rac)-NNC 55-0396
  • HY-113037B
    Farnesyl pyrophosphate
    		Agonist
    Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
    Farnesyl pyrophosphate
  • HY-116400
    BN 50341
    		Antagonist
    BN 50341 is an orally active anticalcic agent and a benzazepine derivative. BN 50341 decreases the in vivo electrically induced thrombus formation in rat or guinea-pig artery and can be utilized in cardiovascular research.
    BN 50341
  • HY-12650A
    (rel)-Mirogabalin
    		Inhibitor
    (rel)-Mirogabalin ((rel)-DS5565) is a voltage-dependent calcium channel inhibitor that acts on the α2δ-1 subunit.
    (rel)-Mirogabalin
  • HY-12515B
    (S)-Nicardipine
    		99.25%
    (S)-Nicardipine ((S)-YC-93 free base) is the less active S enantiomer of Nicardipine. Nicardipine is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
    (S)-Nicardipine
  • HY-108974S
    Drotaverine-d10 hydrochloride
    		Antagonist
    Drotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine-d<sub>10</sub> hydrochloride
  • HY-B0612E
    (S)-Lercanidipine hydrochloride
    		Inhibitor
    (S)-Lercanidipine hydrochloride is the S-enantiomer of Lercanidipine hydrochloride. (S)-lercanidipine hydrochloride is a potent calcium channel blocker.
    (S)-Lercanidipine hydrochloride
  • HY-B1430R
    Butamben (Standard)
    		Inhibitor
    Butamben (Standard) is the analytical standard of Butamben. This product is intended for research and analytical applications. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions.
    Butamben (Standard)
  • HY-P5796
    FS-2
    		Inhibitor
    FS-2 is a potent and specific L-type CaV channel inhibitor. FS-2 inhibits high K+ or glucose induced L-type Ca2+ influx in RIN beta cells.
    FS-2
  • HY-W184837
    m-Nisoldipine
    		Antagonist
    m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases.
    m-Nisoldipine
  • HY-147639
    Cav 2.2/3.2 blocker 1
    		Inhibitor
    Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC50 values of 78 μM and 80 μM against Cav2.2 and Cav3.2, respectively. Cav 2.2/3.2 blocker 1 can penetrate the CNS.
    Cav 2.2/3.2 blocker 1
  • HY-B0612B
    (S)-Lercanidipine
    		Inhibitor
    (S)-Lercanidipine is a calcium channel blocker with antihypertensive and neuroprotective activities. (S)-Lercanidipine reduces oxidative stress and protects auditory sensory hair cells from noise-induced damage. (S)-Lercanidipine showed significant protective effects on cell viability in in vitro experiments, especially at low concentrations. (S)-Lercanidipine has been found to effectively reduce the hearing threshold of mice after noise stimulation and protect the survival of outer hair cells. The antioxidant properties of (S)-Lercanidipine are reflected in its increased expression of antioxidant enzyme genes and decreased expression of oxidative enzyme genes. (S)-Lercanidipine administration is effective in reducing noise-induced hearing loss both before and after noise exposure. (S)-Lercanidipine may alleviate noise-induced hearing loss and protect the survival of outer hair cells through its antioxidant mechanism.
    (S)-Lercanidipine
  • HY-P3041
    Chromostatin (bovine)
    		Inhibitor
    Chromostatin bovine is a chromogranin A (CGA) derivative peptide, which inhibits postassium or carbamoylcholine induced catecholamine release with an ID50 of 5 nM. Chromostatin bovine reduces calcium flux, enhances the desensitization process of the cholinergic-evoked secretory response and modulates the endocrine response associated with catecholamine.
    Chromostatin (bovine)
  • HY-156664
    Calcium Channel antagonist 3
    		98.0%
    Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC50 value of 5-20μM.
    Calcium Channel antagonist 3
  • HY-12515C
    (R)-Nicardipine
    		99.64%
    (R)-Nicardipine ((R)-YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
    (R)-Nicardipine
  • HY-13764A
    dl-Tetrandrine
    		Inhibitor
    dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca2+ influx with an IC50 value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal.
    dl-Tetrandrine
  • HY-148862
    Cavα2δ1&NET-IN-1
    		Inhibitor
    Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Cavα2δ-1 with a Ki of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a Ki of 383 nM and IC50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain.
    Cavα2δ1&NET-IN-1
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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